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EBUS is a procedure that aids in the diagnosis and staging of cancers of the chest. The management of lung and other thoracic cancers depends heavily on the extent of disease, which is based on the involvement of lymph nodes in the center of the chest (the mediastinum). Historically, evaluation of these lymph nodes required an invasive surgical procedure called mediastinoscopy, which entails an incision in the neck and dissection of the lymph nodes off the major vascular and airway structures. In selected cases, mediastinoscopy has been replaced, at least as an initial diagnostic test, by EBUS. EBUS involves passing a long, thin flexible camera called a bronchoscope into the airway under light anesthesia. The airway is visualized and extensively inspected for any abnormalities. Suspicious lymph nodes previously identified on CT scan are located using an ultrasound probe built into the bronchoscope. A thin needle is passed out of the bronchoscope, through the wall of the airway and into the lymph node and a biopsy is taken. Depending on the results of the biopsy, mediastinoscopy may be avoided, but it may still be necessary if the EBUS biopsy is non-diagnostic. Some lymph nodes are difficult to reach using EBUS, and a similar procedure with the probe in the esophagus instead of the airway, called endoscopic ultrasound or EUS, may also be necessary.
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